- Selective breeding reduces the gene pool - the number of different alleles in a population
- Breeding from the best animals or plants, which are all closely related, means you are inbreeding
- This can cause health problems because there is a higher risk of organisms inheriting harmful genetic defects when the gene pool is limited
- There can be a serious problem if a new disease appears because there isn't much variation in the population, so they are all closely related to each other - if one can be killed by the disease, the others are likely to suffer as well
- Selective breeding - reduction in number of different alleles - less chance of any resistant alleles beign present in the population
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