Scott-Van Zeeland et al (2013)

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Aim

To investigate genetic variants assiciated with AN development 

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Sample

DNA from 261 AN females either seevre or early onset, Mean age 14. 

73 control Females

Gathered using Beck's drpression inventory and Yale-Brown-Cornell Eating Dosroders scale 

Additional 500 AN (mean of 16) and 500 non-AN sufferers using Price foundation sample Repository used as a comparison to identify if the orrect gene was being investigated

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Procedure

Sample's scores on Beck's inventory and the Yale-Brown Scale gathered. DNA tests carried out to see if a Gene is more prevolent in AN sufferers 

152 Candidate Genes identified as being involved with Feeding behaviour, dopamine, Seratonin  

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Results

The EPHX2 Gene was worth further investigation- showed the greatest variation between AN patients and non-sufferers 

EPHX2 known to influence cholestrol- AN patiants have high cholestrol even though theyre malnourished (re-eating treatments should not avoid high cholestrolm food) 

This gene is more prevelant in females 

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Conclusion

Evidence suggests a variant of EPHX2 gene may increase AN risk, shows further reserach into Bio causes is needed. 

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Issues

Low in Validity- use of self reports. Means the the study is open to SDB as ppts with AN may answer inaccuratly to seem closer to "Normaility" and so the results may not be true representations of actual results- lowering the Validity 

Qualititative collected in self reports- procides indepth thoughts to be gathered and so a more persoanl account is given for diagnosing AN. 

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