Schizophrenia key studies

?

Cheniaux et al. (Weakness of diagnosis)

Had 2 psychiatrists idenpendently diagnose 100 patients using the DSM-5 and ICD-10 .

Inter-rater reliability was poor:

  • psychiatrist 1 diagnosed 26 with DSM & 44 with ICD
  • psychiatrist 2 diagnosed 13 with DSM & 24 with ICD

This is a weakness of the diagnosis of schizophrenia

Validity is also poor:

(To assess the validity we use criterion validity to see if different assessment types arrive at the same diagnosis for the same patient)

  • the assessment systems didn't arrive at the same diagnosis for the same patient
  • schizophrenia is more likely to be diagnosed with the ICD than the DSM
  • suggest that either schizophrenia is over diagnosed with the ICD or under diagnosed with the DSM
1 of 4

Buckley et al. (Support for Co-morbidity as a weak

Found that 50% of patients with schizophrenia also had depression and substance abuse in just under 50%.
29% had Post- traumatic stress disorder and 23% had OCD

Is severe depression is similar to SZ are they the same condition?

2 of 4

Gottesman (large scale family study supporting gen

Found that as genetic similarity increases the likelihood of both individuals developing schizophrenia.
Concordance rates in monozygotic twins (48%)
Compared to concordance rates in dizygotic twins (17%)

3 of 4

Ripke et al. (Support for candidate genes)

Studied 37,000 schizophrenia patients and compared their genes with 113,000 controls

-found that there were 108 separate gene combinations that are linked to an increased risk of schizophrenia

-genes associated with an increased risk also include those that code for the functioning of several neurotransmitters such as dopamine

4 of 4

Comments

No comments have yet been made

Similar Psychology resources:

See all Psychology resources »See all Schizophrenia resources »