Vibrio cholerae is transmitted by ingestion of water or more rarely food thats been contaminated with faecal material containing this pathogen. Once ingested:
Almost all vibrio cholerae bacteria ingested by humans are killed by the acidic conditions in stomach. Some survive especially of P.H is above 4.5
When surviving bacteria reach small intestine they use their glagella to propel themselves in corkscrew like fashion through mucus lining of intestinal wall.
They then start producing toxic protein which has 2 parts. The first binds to specific carbohydrate receptors on cell surface membrane. As only epithelial cells of small intestine have these specific receptors, it explains why cholera toxin only affects this region of the body.
Other toxic part enters epithelial cells which causes ion channels of cell surface membrane to open, so chloride ions that are normally contained within the epithelial cells flood into the lumen of the intestine.
Loss of chloride ions from epithelial cells raises their water potential while the increase of chloride ions in the lumen of the intestine lowers its water potential.
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