Challenges the clonal selection model as this does not kill semi-allogenic foetus.
1 progenitor gives rise to different receptors, each of single antigenic specificity, further diversity induced by rearrangement of RAG genes in thymus giving different TCRs.
T-cells which react to self antigens via their TCR are deleted in central thymic selection.
A specific antigen stimulates CD8+ cells with specific TCRs via MHCI and stimulates CD4+ cells with specific TCRs via MHCII on APC.
This stimulates the T-cell to undergo clonal expansion and gives rise to many identical cells all with this specific TCR which reacts to the antigen
Cyotokines then determine further differentiation of cell types to produce different classes of T-cells
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