Drosophila - mutations of period gene - circadian clock in mammals
SCN - 2 proteins in mammals
- CLOCK
- CYCLE or BMAL1
Clock + Cycle/Bmal1 proteins = a dimer
CLOCK/BMAL1 heterodimer: promotes transcription of 2 genes:
- Period (per) + their paralogs
- Cryptochrome (cry) + their paralogs
1. Per and Cry proteins - bind to each other / 3rd one = Tau
2. PER/CRY/TAU - protein complex -> enters nucleus -> stops per + cry transcription
3.Thus no new proteins made until 1st set degrades
4. Cycle begins again every 24 hours
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