• Created by: Megan
  • Created on: 07-03-14 21:06

Meiosis Phases

Prophase I -> each chromosome duplicates and remains closely associated - sister chromatids. Crossing over occurs late in this stage

Metaphase I ->homologous chromosomes align at the equatorial plate - chiasmata remain in place holding the pairs together on the spindle so that in Anaphase, one member goes to each pole

Anaphase I -> homologous pairs separate with sister chromatids remaining together

Telophase I -> Two daughter cells are formed - each contains one chromosome of the homologous pair 

Prophase II -> Centrioles replicate but DNA does not replicate

Metaphase II -> Chromosomes align at the equatorial plate

Anaphase II -> Centromeres divide and sister chromatids migrate separately to each pole

Telophase II -> Cell division is complete. Four haploid daughter cells are obtained - they are all genetically different

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Crossing Over

  • each chromosome is divided into two chromatids
  • homologous chromosomes twist around each other
  • This tension causes breaks 
  • cross overs are called chiasmata
  • fragments may attach to other homologous chromosome
  • creates a new genetic combination and viariation in gametes
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Increasing Genetic Variation

  • Crossing over shuffles alleles
  • Genetic reassortment due to the random distribution and subsequent segregation of the chromosomes in the homologous pairs during meiosis I
  • Genetic reassortment due to random distribution and segregation of sister chromatids at meisos II
  • Random mutation

Fertilisation increases genetic variation by randomly combining chromosomes at the two chromosomes are unrelated - 1 of 300 million sperm will fertilise the egg

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Re-assortment of Chromosomes

  • Random distribution of maternal and paternal chromosomes on the spindle equator that then segregate in Anaphase 1
  • Gamete acquires a different mix of maternal and paternal chromosomes

Re-assortment of Chromatids

  • Random distribution of the spindle equator of sister chromatids at Metaphase II
  • Crossing over prevents sister chromatids being genetically identical
  • the alignment at metaphase II determines how they segregate at Anaphase II


DNA mutation may occur during interphase during replication - chromosome mutation may also occur and these increase genetic variation

Advantage - they increase variation

Disadvantage - Requires a lot of energy, Organisms more vulnerable when pregnant

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