The Krebs Cycle (Mitochondrial Matrix)
- Acetate is offloaded from CoA and joins oxaloacetate (4C) to form citrate (6C)
- Citrate is decarboxylated and dehydrogenated to form a 5C compound. The hydrogen atoms are accepted by NAD.
- The 5C compound is decarboxylated and dehdrogenated to form a 4C compound and another molecule of reduced NAD.
- The 4C compound is changed to another 4C compound. ADP is phosphorylated to produce ATP (substrate level phosphorylation)
- The second 4C compound is changed to another 4C compound. A pair of hydrogen atoms are removed by FAD.
- The third 4C compound is further dehydrogenated and regenerates oxaloacetate. Another molecule of NAD is reduced.
2 turns of the cycle = one molecule of glucose.
Products: 6 reduced NAD, 2 reduced FAD, 4 CO2, 2 ATP (for one glucose)
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