Intravenous anaesthetics

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Potentiates GABA receptors

It is readily metabolized in the liver and distributed in fatty tissue

Most commonly used as an induction agent as patient wakes up within 5-10 minutes 

Alters patients mood and preventing vomiting 

Used in 'Total Intravenous Anasthesia' as maintance agent, given along within opioid and muscle relaxant 

Can cause apnoea and a fall in BP. 

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Component used to help people to sleep inducing anaesthesia 

Potentitates GABA receptors 

Cross the blood brain barrier producing unconciousness with 20-30 seconds due to high lipid solubility 

Distributes rapidly to other tissues so regain conciousness with 10-20 minutes

Due to slow metabolism in the liver and a half life of 9 hours; sedative effects can presist for 24 hours and accumulate 

Poor analgesic and muscle relaxant 

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Induction of anaesthesia

Rapid recovery without any hangover 

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Induces anaesthesia smoothly 


Moderate muscle relaxation 

Has an association with severe hepatotoxicity 

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Fall in BP

Muscle relaxation and potentiate muscle relaxants 

Risk of hepatotoxicity but less than halothane 

Less potanet than halothane 

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Used for maintaing anaesthesia and analgesia 

Used in 500-66% with Oxygen 

As potency is very low, useed with other anaesthesia agents 

Used in obstetrics for labour pains. 

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