- Created by: superstar101
- Created on: 04-05-15 11:22
Normal alleles of gene inserted into target cells using Genetically modified Virus or liposomes (spherical phospholipid bilayers)
Normal form of gene is transcribed and translated
a functioning protein is produced in target cells. (in CF gene CFTR protein is produced and incorparated into cell membrane, restoring ion channel and avoiding symptoms of CF)
Genetically Modified virus
- DNA that allows it to replicate is removed - replaced with normal allele of desired gene along with promotor sequence that initicates transcription/translation of gene.
in CF viral DNA remains independent within nucleus of our cells
X causes inflamatory response with symptoms such as headache fever and raised heart rate.
- Copy of normal allele inserted into loop of DNA - called a plasmid
- positively charged head groups of phospholipids combine with DNA to forn liposome-DNA complex