Size & growth: benign = large but slow, malignant = large and rapid.
Nucleus: benign = normal, malignant = larger, darker, abundance of DNA.
Appearance: benign and malignant = discolouration.
Differentiation: benign = remains specialised, malignant = may become unspecialised.
Adhesion: benign = can produce adhesion molecules - stick together so remains a primary tumour, malignant = no adhesion molecules - forms secondary tumours (metastasis).
Capsule: benign = surrounded by dense tissue>remains compact, malignant = no capsule>tumour grows finger - like projections into surrounding tissue.
Threat to life: benign = not high although may disrupt function of vital organ, malignant = often.
Location of effects: benign = localised, malignant = often systemic.
Surgery?: benign = yes, malignant = surgery+chemotherapy+radiotherapy.
Reoccurrence?: benign = rare, malignant = frequent.
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