There are several factors that suggest that biological mechanisms may play a part in depression:
physical changes - The symptoms of depression include physical changes (e.g. sleep and appetite distubance, weight changes, fatigue and lack of energy).
similar symptoms - There is great similarity in the symptoms across cultures, races, gender and ages.
Families - Depression runs in families (although this could be due to a shared environment).
Drug treatments - Antidepressant medication can be successful in treating depression (although this does not in itself prove an underlying biological cause).
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