Do not compete for the active site
Instead they attach to the molecule in a region away from the active site this distorts the tertiary structure of the enzyme molecule and changes the shape of the active site.
Enzyme-substrate molecules can no longer form and so no product is produced and the reaction rate decreases.
The level of inhibition depends on the number of inhibitors present. Can stop reaction completely.
Permanent iinhibitors:
Most iinhibitors aren't permanent and are reversible but some aren't and they permanently denature the enzyme.
Inhibition is not always a bad thing. Can control reaction rates.
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