Mode of Action
- Nicotine enters the body and is transported to every cell in the body via the blood stream.
- Nicotine arrives at the synapse and binds to the acetylcholine receptors.
- This binding causes the receptor to open allowing ions to flood the post synaptic cleft causing noradrenaline to rise. Nicotine mimics acetylecholine.
- This causes neural firing of acetylcholine, which has an effect as it reaches the reward pathway.
- The positive relaxing and reduce of anxiety is felt as the reward pathway is stimulated by endorphins.
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- buring in the mouth
- sickness/stomach pains
- dizziness and headaches
- increased blood pressure
- decrese in anxiety
- improves memory/attention
- reduce lung efficeny
- reduce heart efficieny
- internal buring
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- Tolerance is reached rapidly
- Brain changes occur to accept nictoine in the body.
- Become used to oral stimulation
- Strong postive reinforcement
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- The body produces more acetylcholine receptors to deal with increased acetylcholine. Tolerance is increased only after a few days of exposure.
- The plateau is reached very quickly, increasing to a high level of nicotine intake.
- Increased consumption of nicotine means that individuals become addicted very quickly.
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- desire for oral gratification
- poor concetration
- increased anxiety
- memory problems
- sleeping issues
- increased appetite
- (opposite to the effects of nicotine)
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