Drugs of Abuse - GHB

Drugs of Abuse - GHB

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What is the chemical name for GHB?

What is GHB?

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  •   The protonated form of GHB is white and odourless and solid when converted into a metal sal.
  •   The KGHB and NaGHB salts are both very hygroscopic.
  • GHB is mostly found as an colourless  liquid slightly salty (Advantageous to use to intoxicate somebody).
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How is GHB controlled in legislation?

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  • Class C drug since 1st July 2003 in the UK.
  • Federally controlled (schedule 1) since March 2000 in USA.
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What are some street names for GHB?

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  • GHB
  • Liquid ecstasy
  • Liquid X
  • Easy Lay
  • Scoop
  • Fantasy
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What is the history of the drug?

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It was origionally designed to be an anasthetic which can cross the BLOOD BRAIN BARRIER.

It has been recently used to treat narcolepsy and catalepsy, and to help alcohol/opiate withdrawal.

GHB is currently heavily used in DFSA (drug-facilitated sexual assaults) in the same way as Rohypnol and Ketamine.

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How could you describe GHB chemically?

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It is a small endogeneous polar compound.

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What are some similar nutritional and dietary pros

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  • Blue Nitro (GBL)
  • Renewtrient (GHB)
  • Midnight Blue (GBL)
  • SomatoPro (1,4-BD)
  • Serenity (1,4-BD)
  • Enliven (1,4-BD)
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What is the origin and history of GHB starting fro

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1874 - GHB first synthesised by Alexander Zaytsev in Russia.

1960's - Used for human research.

70's, 80's and 90's - Widely used in Europe as a sleeping agent, and anti-depressant.

90's - GHB used in DFSA and robbery.

2000's - GHB banned.

2009 - Dangerous industrial use of GHB, precursor banned (GBL), and medical use.

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What is meant by 'in vitro'?

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  • GHB is converted into GBL in alkaline solution.
  • Converted back (reverse reaction) in acidic solution.
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What are 2 chemical precursors of GHB?

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  • GBL Gamma-butyrolactone
  • 1,4 BD 1,4 butandiol
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What is GBL? What is it's chemical structure?

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GBL industrial use: difficult to estimate after recent ban. No longer officially used.

- Viscous clear liquid

- Used instead of GHB in 50% of the cases

- Very rapid conversion into GHB in the body

- Possible slightly delayed effect


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What is 1,4 butandiol? What is its chemical struct

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1,4-Butanediol industrial use: solvent in plastics, elastic fibers and polyurethanes manufacture.

World production is about one million metric tons per year (Still not banned). Prosecution possible.

“One Comma Four”

- Viscous clear liquid

- Rapid conversion into GHB in the body


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What is the chemical structure of GHB?

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What are the pharmalogical effects of GHB?

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1. GHB dose

2. Nausea

3. Dizziness

4. Drowsiness

5. Agitation

6. Visual Disturbance

7. Depressed breathing

8. Uconsciousness

9. Amnesia

10. Coma

11. Death

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