alcohol and opium were used
however they had litte sucess in easing pain during an operation
in 1844 laughing gas was used
it was used in dentistry in the USA
it failed to ease pain (it just made them laugh) and the pateint remained concious
ether was used in 1846.
it made patients totally unconcious and lasted a long time
some patients who where under the influence of ether would cough during the operation and be sick afterwards.
it was highly flammable and hard to transport due to it being in a heavy glass bottle
chloroform was used in 1847.
it appeared to have little side effects and very effective.
hiwever it was difficult to get the dose right.
some patients died due to the effect it had on their heart.
but an inhaler was invented to regulate the dosage.
1884 and 1905
in 1884 cocaine was used as a local anaesthetic
in 1905 a less addictive version - novocaine - was used as a general anaesthetic.