If the analyte dissolves in water a solvent is added that wont change things (immiscible)
- The analyte will diffuse across the boundary to reach equilibrium although this can take time
- If the two phases are mixed (for example via shaking within a column) then this can reduce the time before equilibrium is reached
- Several small samples rather than one large one can make the process much more efficient
- These methods are extremely common but they cannot isolate one specific item/molecule very often.
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