Initiation: Research has found that addictive drugs stimulate a reward circuit in the brain which triggers the release of dopamine and effectively tells the brain to do it again. For example crack cocaine triggers a rapid release of dopamine into the mesolimbic pathway which then gets the brain to link the pleasurable experiences with the drug.
Maintainance: Chronic exposure to drugs eventually results in a reduction of positive reward circuits in the brain (down regulation). The individual then creates a stress situation characterised by withdraw symptoms, this negative state then becomes the driving force in the drug craving as people no longer take the substance for the pleasurable effect, but instead as a way of avoiding having to experience the negative effects.
Relapse: Even though the drug no longer produces much of a reward the brain still recieves signals that says if you take it you will be rewarded due to the memories of it. Addicts try to abstain from it but are constantly surrounded by cues which trigger the same response, even though they know there is no reward coming there is still a release of dopamine. The frontal cortex is less effective at making decisions which heightens the risk of relapse.
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