Altman et al (1996) found that dopamine is increased by nicotine and alcohol.
People with susceptibility to addiction may have a more sensitive mesolimbic dopamine pathway, so would gain more reward.
Research has found low levels of serotonin in addicts - serotonin might usually regulate impulsive behaviour by limiting reinforcing effects.
Opoid neurotransmitters such as endorphins are activated by pleasurable states and also by drugs. Naltrexone is a drug used to treat alcoholism and works by blocking opoid receptors, reducing pleasurable effects.
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