> Heritability estimates of 50 +60% for both men and women (McGue 1999)
>Meta Analysis: found heritability of illicit drug abuse + dependence significantly affected by genetic influence
> Family and twin studies demonstrate genes contribute to development of alcohol dependence
> Twins have also established that co-occurrence of some disorders are influenced by genetic factors
>Kendler et al (2003) analysed data from Virginia twin registry and found common genetic factor contributed to total variance in alcohol dependence, illicit drug use + dependence, and adult anti- social behaviour --> Findings: significant proportion of genetic influences on alcohol and drug dependence manifests itself in general disposition towards behavioural disorders which may lead to alcohol dependence.
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