(Depression is thought to be due to insufficient ammounts of neurotransitters like serotonin being produced in the nerve endings (synapse). In noral brains, neurotrasmitters are constantly being released from nerve endings, stimulating the neighbouring neurons . To terminate their action , neurotransmitters are reabsorbed into the nerve endings and broken down by an enzyme.)
Antidepressants work by reducing the rate of reabsorption, or by blocking the enzyme that breaks down the neurotransmitters. Both of these mechanisms increase the ammount of neurotransmitter available to excite neighbouring cells.
The most commonly prescribed antidepressant drugs are selective seretonin reuptake inhibitors or SSRIs, such as Prozac.They work by blockig the transporter mechanism that reabsorbs serotonin into the presynaptic cel after it has fired so more of the serotonin is left in the synapse, prolonging it's activity and making transmission of the next impulse easier. Patients taking SSRIs are twice as likey to commit suicide (Ferguson et al, 2005)
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