Problems with the serotonin explanation: SSRIs are ineffective when used with AN patients. Ferguson et al found no change in symptoms between AN patients taking SSRI and patients with similar characteristics who weren't taking them. However, Kaye et al found, when used with recovering AN patients the drugs were effective in preventing relapse. Suggests that malnutrition-related changes in serotonin function might negate the action of SSRIs - seem to only become effective when weight returns to a more normal level.
Research support for the dopamine: Research supports the role of dopamine in AN symptoms. Food aversion, weight loss etc. found to be related to increase activity in dopamine pathways. Other evidence = increased eye-blink in AN compared to controls - indicative of higher levels of dopamine activity in the brain. Barbato et al found a signifiant correlation between blink rate and duration of AN - suggests the relationship between dopamine activity and AN symptoms develop overtime.
Advantages of biological explanations of AN: Advantage of reducing the stigma that a patients challenging behaviour with AN is their fault. Also the possiblity of treating AN by regulating the brain areas involved in the behaviours that are characteristic of AN. Lipsman et al used deep brain stimulation to change activity in the subcallosal cingulate in patients with chronic AN - led to improvements in mood.
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