1. Smoking
- Carbon Monoxide:
combines with haemoglobin in RBC to from carboxharmoglobin. Reducing oxygen-carring capacity of blood. To supply enough oxygen, heart works harder. leads to angina.
- Nicotine:
Stimulates production of adrenaline, increasing heart rate and raises BP. Makes platelets more 'sticky' leading to higher risk of thrombosis, hence myocardial infarction
2. High Blood Pressure
- higher pressure in arteries, heart work harder to pump blood into them
- more likely to develop aneurysm and burst
- to resist, wall thicken and harden, restricting flow of blood
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