- Able to respond over a wide range of temperatures
- Phagocytic activity of macrophages can be affected
- Wall lizards have highest macrophage activity at 25*C
- Temperatures can also affect pathogen and therefore prevalence
What Happens to the Immune System During Hibernation?
- Especially in mammals and reptiles
- Immunity decreases as metabolic rate decreases
- Thymic involution occurs (fewer T cells)
- In the Spring: redevelopment of the thymus reconstitutes their T cell population
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