In areas where malaria is endemic, sickle cell anaemia has a heterozygous advantage.
- HbA HbA
- Disadvantageous
- Malaria affects the person normally
- HbA HbS
- Advantageous
- Causes malaria infection to stay in body longer
- Immune system has longer to react
- Composition of RBC changed, parasite can't reproduce as much.
- HbS HbS
- Disadvantageous
- Person has sickle cell anaemia
Causes an increase in frequency of HbA HbS.
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