TYPES OF MUTATIONS

NON-SENSE

MIS-SENSE

SILENT

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BASE SUBSTITUTION
TYPE OF MUTATION NONSENSE MIS-SENSE SILENT
No change in the amino acid
Prematurely stops the sequence Brings in a code for a different
sequence ­ neutral mutation with
DESCRIPTION of amino acids and causes amino acid (harmful and
neither a positive or negative
incomplete protein potentially harmless)
effect
NORMAL DNA SEQUENCE TAC AAG ATG TTC TAC AAG ATG TTC TAC AAG ATG TTC
MUTANT DNA SEQUENCE TAC AAG ATG STOP TAC AAG ATA TTC TAC AAG ATG TTC
mRNA SEQUENCE AUG UUC UAC STOP AUG UUC UAU AAG AUG UUC UAC AAG
CAN BE HARMFUL/HAMRLESS.
PREMATURELY STOPS THE
MAY CHANGES THE TERTIRY NEUTRAL MUTATION. IT HAS
SEQUENCE OF AMINO ACIDS AND
POSSIBLE CONSEQUENCES STRUCTURE OF THE PROTEIN NEITHER A POSITIVE OR
CAUSES AN INCOMPLETE
MEANING IT CANT FUNCTION NEGATIVE CONSEQUENCE
PROTEIN
FULLY

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