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The body's response to STRESS!
Sympathetic - Adrenal- Medullar (SAM) Pathway
Fast Acting

Hypothalamus
Commands the
Autonomic nervous system
To activate the
Sympathetic nervous system pathways
Running to the
Adrenal medulla
Within the
Adrenal glands
To release
Adrenaline and noradrenalin (fight or flight)
Into the
Bloodstream
Which leads to the…

Page 2

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Hypothalamic ­ Pituitary ­ Adrenal (HPA) Axis
Slow acting

Hypothalamus
Stimulates the release of
Cortico-releasing hormone
Which stimulates the release of
Adrenocorticotrophic Hormone (ATCH)
From the
Pituitary gland
Into the
Blood stream

The ACTH
Travels to
Adrenal cortex
Which stimulates the release of
Cortico steroids
Into the
blood stream
Which…

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