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Neuro-anatomical explanations
· MRI technology has enabled us to identify structural abnormalities in
the brains of schizophrenia sufferers.
· There is increasing evidence that the brains of sufferers of
schizophrenia have structural damage.
· This brain damage may have occurred at birth and caused the brain
to fail to develop properly. Or damage may have occurred as the
result of developing schizophrenia.
1. Enlarged ventricles
2. Specific brain abnormality…read more

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Images handout
· Refer to the first images.
· What can you see?…read more

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1. Enlarged Ventricles
Numerous brain abnormalities have been found in
schizophrenia. Using PET, MRI and CAT scans
researchers have discovered that many schizophrenia
patients often have enlarged cranial ventricles (cavities
in the brain that that supply nutrients, remove waste &
transport cerebrospinal fluid), especially the third
ventricle, and decreased cerebral size compared with
control groups. The ventricles of a sufferer are on
average 15% larger than normal (Torrey, 2002).
Sufferers with this dysfunction tend to display more positive
symptoms and have more cognitive disturbances.…read more

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Evidence
· Pahl, Swayze & Andreasen (1990)
Meta-analysis of 50 studies
Majority found abnormally large lateral ventricles (liquid
filled cavities) in schizophrenics
· Suddath et al (1990)
Used MRI (magnetic resonance imaging) on MZ twins
One twin had schizophrenia
Schizophrenic twin showed enlarged ventricles &
reduced anterior hypothalamus
Schizophrenic twin easily identified in 12 of 15 cases by
MRI alone!…read more

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