First 541 words of the document:
1. Naked mole rats show various adaptations to their particular environment. Give an example of (a)
a behavioural adaptation, (b) a physiological adaptation, and (c) an anatomical adaptation
exhibited by these animals.
2. Give two examples of features that help thermoregulation in most mammals that are reduced or
absent in Naked Mole rats and explain how each operates to help achieve thermoregulation.
3. Give one advantage and one disadvantage in being poikilothermic in comparison to
4. The non-reproductive individuals in eusocial animals do not directly transfer their genes to
offspring. In spite of this there must still be a genetic advantage in being eusocial suggest what
this must be.
5. What evidence would scientists look for when searching for evidence of heart disease in naked
6. What is a free radical, how might we minimise the effect of these to our bodies?
7. Mole rats have more stable proteins. State 3 ways in which the structure of the protein might be
8. Suggest how extra molecules attaching to proteins might affect their structure and function.
9. Suggest what processes would be altered by the cancer causing genes.
10. Describe the techniques that would be used to insert the cancer causing genes into the cells of
11. Give 6 ways in which the body can be immunologically compromised
12. How might the immune system of immune compromised mice differ from normal mice.
13. Name the process by which cells replicate (p14) and describe the events that take place in the
main events of this process.
14. Suggest how cells might `recognise' the presence of other cells (contact inhibition)
15. Why are mice used so extensively in drug treatment studies
16. Explain how transcription factors bring about expression of a gene (p24)
17. P30 Explain how an extracellular signal might ultimately lead to inhibition of cell division
18. Describe the procedures a potential new anti-cancer therapy would have to go through before it
could be licenced as a drug.
19. Explain how impulses would be transmitted from the pain receptors of a rodent to its central
20. What is the sequence of neurones impulses would pass through, to result in withdrawing a hand
from a hot stove.
21. Describe the responses that humans would show if they were breathing air with 5% Carbon
dioxide, and explain how these responses are brought about. Would this response be an
example of negative or positive feedback? Explain your answer
22. A brain deprived of oxygen will lead to a brain deprived of ATP/energy. Describe the role of
oxygen in the production of ATP.
23. Explain how populations of Naked Mole rats have evolved to be resistant to hypoxia.
24. Use of modern scanning techniques has transformed our understanding of the localisation of
function in the brain. Describe how fMRI can be used to study brain function and compare this
with early techniques that were used to investigate brain function.
25. From p47 why are the new prosthetics being developed at UCL less likely to damage tissues, and
why is there a problem that must be overcome with these prosthetics.
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The queen prevents non-breeders becoming reproductive by altering the hormonal balance in
the non-breeders. Compare and contrast the ways in which this kind of communicatiodiffersfrom
27. Describe the techniques and procedures that would be used to produce a DNA fingerprint from a
Naked Mole Rat.
28. Suggest why out-breeding is likely to increase the long term survival of Naked Mole Rat