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Mutations

A mutation is a change in the amount of, or arrangement of, the genetic material of a cell.

DNA is a double helix molecule and its structure is designed to make it very stable and prevent
mistakes in its genetic code.
DNA mutations can occur during DNA replication either…

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Huntington disease results from an expanded nucleotide repeat-a stutter. The normal gene for
Huntington protein has repeating CAG sequences. If these expand to above a threshold number,
the protein is altered sufficiently to cause Huntington disease.
Examples of possible mutations:

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