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Issue date: January 2007 NHS
Review date: March 2010
National Institute for
Health and Clinical Excellence
Quick reference guide
Naltrexone for the management of
1 Guidance 2 Implementation
1.1 Naltrexone is recommended as a treatment option NICE has developed tools to help organisations implement
in detoxified formerly opioid-dependent people this guidance (listed below). These are available on our
who are highly motivated to remain in an website (www.nice.org.uk/TA115).
abstinence programme. · A costing statement explaining the resource impact
1.2 Naltrexone should only be administered under of this guidance.
adequate supervision to people who have been · Audit criteria to monitor local practice.
fully informed of the potential adverse effects of
treatment. It should be given as part of a NICE is developing a suite of implementation tools to
programme of supportive care. coincide with the publication of its drug misuse guidance
(see `Related NICE guidance' section).
1.3 The effectiveness of naltrexone in preventing
opioid misuse in people being treated should be
reviewed regularly. Discontinuation of naltrexone
treatment should be considered if there is evidence
of such misuse.
NICE technology appraisal guidance 115
This guidance is written in the following context
This guidance represents the view of the Institute, which was arrived at after careful consideration of the available
evidence. Healthcare professionals are expected to take it fully into account when exercising their clinical judgement.
This guidance does not, however, override the individual responsibility of healthcare professionals to make appropriate
decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.
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Further information `Understanding NICE guidance'
Quick reference guide Information for people who are opioid dependent and their
carers is available from www.nice.org.uk/TA115publicinfo
This has been distributed to healthcare professionals
working in the NHS in England and Wales (see For printed copies, phone the NHS Response Line on
www.nice.org.uk/TA115distributionlist). It is available 0870 1555 455 (quote reference number N1177).
For printed copies, phone the NHS Response Line on Related NICE guidance
0870 1555 455 (quote reference number N1176).…read more