Other slides in this set

Slide 2

Preview of page 2

Here's a taster:

You should be able to:
· Outline the link reaction, with reference to
decarboxylation of pyruvate to acetate and
the reduction of NAD, and state that it takes
place in the mitochondrial matrix.
· Explain that coenzyme A carries acetate
from the link reaction to Krebs cycle.
· Outline the Krebs cycle, including the roles
of NAD and FAD, and substrate-level
phosphorylation, and state that it takes
place in the mitochondrial matrix.…read more

Slide 3

Preview of page 3

Here's a taster:

The link reaction
· Changes pyruvate (produced during
glycolysis) into a 2-C compound (acetate).
· Pyruvate dehydrogenase removes
hydrogen atoms from pyruvate.
· Pyruvate decarboxylase removes a
carboxyl group from pyruvate.
· NAD accepts the H atoms
· CoA accepts acetate, to become acetyl
CoA (carries acetate to Krebs cycle).…read more

Slide 4

Preview of page 4

Slide 5

Preview of page 5

Here's a taster:

The link reaction
2pyruvate + 2NAD+ + 2CoA 2CO2 + 2reduced NAD + 2acetyl CoA
· NAD+ indicates NAD in the oxidised state.
· Note that no ATP is produced.
· Each reduced NAD will take a pair of H atoms
to the inner membrane to be used during
oxidative phosphorylation to make ATP.…read more

Slide 6

Preview of page 6

Here's a taster:

The Krebs cycle
Takes place in mitochondrial matrix.
1. Acetate is offloaded from CoA and joins
with 4C oxaloacetate to form 6C citrate.
2. Citrate is decarboxylated and
dehydrogenated to form a 5C compound.
The pair of H atoms is accepted by NAD,
which becomes reduced.
3. The 5C compound is decarboxylated and
dehydrogenated to form a 4C compound
and another reduced NAD…read more

Slide 7

Preview of page 7
Preview of page 7

Slide 8

Preview of page 8

Slide 9

Preview of page 9
Preview of page 9

Slide 10

Preview of page 10
Preview of page 10

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all resources »