Biological Explanations of Anorexia ESSAY PLAN / NOTES

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B iol
ogica l
E xplanat
ion s o f
Anorexi
a
N er
vosa
AO1: AO2:
Genetics: The
vuln erabi
li
ty
do es not n ece s sar
il
y
(
Fa mi ly
stud ies)
Lil
enfeld et
a l
:
looked
a t eme rge as
ful
l
blown AN.
t
he fa mily
h ist
o ry
of
2 8peo ple
diagnose d
wi
th A N and f
o und a
fami ly
v ul
n er
ab i
l
it
y f
or
t
he d i
sorder .
T hey
found t ha t
r
elati
ves of
anore xics
w ere 71 2x
mo re li
kely
to
sho w
sub t hr
esh o l
d forms of
an or
e xia
(not
qu i
te
mee t i
ng DS M cri
teri
a f
o r
t he disor
der).
(
Tw i
n
studie s) Holl
and et al
: f
ou nd
that G eneti
ca ll
y si
milar
me mb e rs o f
a
family
56% of
t
h e
MZ
twins
in
th e i
r st
ud y
both t end t
o s pend mo r
e ti
me t
o g eth e r
,
so
had A N ,
wh e r
e as onl
y 5% of
the DZ t
w ins environme nt
may be
a
facto r.
bot
h suf
fere d.
C oncord ance r
ate i
s
not 100 %, s o i
t
ca n'
t
be enti
re l
y geneti
c.
Sa mple si
ze of
t
w i
n studies wil l
b e sma l
l.
G eneti
c expl
an at
ions can't
e xp l
a i
n t
he
recent
in crease
in cases of AN .
(
C hro mo some s)
G ri
ce's
e t
a l
:
found AN i
s un l
ikel
y t
o b e cause d
by
a
singl
e
evi
de nce f
o r suscepti
b i
l
it
y
to
AN
o n gen e.
I
t is
a
comp l
e x di
sord er
w ith a
chr
o mo some s.
Th ey
comp a red DNA numb er of
genes i
nv ol
ve d,
e ac h
samp l
e
fr
om peo pl
e wit
h A N ,
wit
h t
hose c ontri
bu ti
ng
a sma l
l
e f
fect
.
bel
on ging
to f
a mil
y me mb ers.
G eneti
c
commo nal
ities eme rged
w he n t
hey l
oo ked
at
f
a mi li
es w it
h
2 or
mo re r
el at
ives
of
A N
wi
th s evere f
o od r
e st
ri
cti
o n.
Neuroanatomy: D avey:
I t
i
s unl
ikel
y that
pr o bl
e ms
Lat
e r al
hypo thalamu s:
Da ma ge t
o
the associat ed
w i
th
the lat
e r
al h yp ot ha l
amu s
l
atera l
hypo tha l
amu s caus es
loss of
are a
ce n t
ral
cau sal
factor of A N .
An i
ma l
appe t
it
e r
e s ul
ting
in a
self sta r
vati
on studi
e s
i ndi
cate t
hat dama g e
to t hi
s pa rt
synd rome .
of
the hy pothal
amu s
results
in l
a ck
of
hun ger
. By
co nt
rast,
those
w ho s uff
er w it
h
AN usua l
ly
report
ex peri
en c i
ng
in tense
hun ger
.
I
nsul a cort
e x :
AN
ca n
be acc ounted f
or
by D i
ff
icul
t to desi
gn t
e sts
tha t
t
ar ge t
t
h e
t
he p r
oblems
in t
h e
neu t
ra l
c i
rcui
try
of
t he insul
a co rt
ex wit
ho ut
a ct
ivat i
ng
th e ma n y
i
nsula cort
e x struct
ure t ha t
hel
ps t
o other
are as of
the
b rai
n to w hic h i
t i
s
i
nteg rate
the f
u ncti
ons of a l
l
t
he possible c onn ect
e d and t
h i
s ma kes t he i
n sul
a
neura l
centr es rel
evant t
o
the feat
ures of c ortex
h ypo t
hesis
ve ry
dif
fic ul
t t
o
test.
AN.
Neurochemistry: N ot
cl
ea r
whether
th ese
se r ot
o ni n
leve ls
Sero tonin:
A N of
ten has
a bn or
ma ll
y hi
g h a re a
ca u se
or ef
fect
o f
AN .
Wh il e
an i
ma l
l
evels of
ser otonin
an d
thi s
c auses studi
e s
h ave show n t
h at
w h en se rotoni n
is
abno r
ma l
ly h i
g h
level
s of anxiet
y. rel
e ased
into
eit
he r
V MH
o r
LH a ni
ma ls .
Sero tonin
p rod uct
ion i
s st i
mu lat
e d
by Stop eat i
ng,
recent research h av e
foun d

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S o
star
vati
o n may act
ual
ly
ma ke peopl
e wit
h A N
than
amo ng cont
rol
s
AN's
feel
bet
ter
.…read more

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