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The Regulation of Blood Glucose

The Pancreas:
Lies below stomach
Has both Exocrine and Endocrine functions.
Secretion of Enzymes (Exocrine Function):
Majority of cells in pancreas manufacture and release digestive enzymes
These cells are found surrounding tiny tubules small groups; into which they
secrete the digestive enzymes into.
The tubules…

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The Secretion of Hormones (Endocrine Function):
Area of pancreas called Islets of Langerhans
o cells ­ manufacture and secrete the
hormone glucagon.
o cells ­ manufacture and secrete the
hormone insulin.
The islets are well supplied with blood capillaries
and so the hormones are directly secreted into
the blood.…

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The increased entry of glucose lowers its level in the blood as its being used (e.g.
glycogenesis, respiration) and as a result the concentration of glucose in the
blood drops to the desired level.
If blood glucose levels are too low:
Low blood glucose concentration detected by cells
cells then…

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1. Hepatocytes have specific receptors for specific hormones to ensure that the
correct actions take place (e.g. for cells glycogenolysis)
2. First Messengers:
Second Messengers:
Cyclic AMP

Key Definitions
Pancreatic Duct ­ tube that collects secretion from the exocrine cells in the pancreas
and carries fluid (pancreatic…


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