- Benign and malignant are terms to describe the behaviour of neoplasms
- Benign and malignant neoplams may be preceded by hyperplasia, metaplasia and dysplasia
- Invasion and metastases are hallmarks of malignancy
- The growth rate of benign neoplasms is slow whereas the growth rate of malignant neoplasms is relatively rapid
- Benign neoplasms have few mitotic figures whereas malignant neoplasms are numerous and usually abnormal
- Benign neoplasms are well-differentiated. Malignant neoplasms have variable differentiation.
- The nuclei of benign neoplasms are often normal compared to the nuclei of malignant neoplasms are hyperchromatic and pleomorphic
- Benign neoplasms have a circumscribed and encapsulated border. Malignant neoplasms have no true capsule and an ill-defined border.