Antipsychotics

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  • Antipsychotics
    • Atypical
      • Dopamine and serotonin
        • Minimises side effects
        • Targets serotonin and dopamine
        • Suppresses psychoses
      • Improving mood
        • Clozapine acts on serotonin and glutamine receptors
        • Reduces depression and anxiety
        • Improves cognitive functioning
        • Is often used in those at high risk of suicide
      • Safety
        • Risperidone is safer than chlorpromazine
        • Fewer deaths due to agranulocytosis
        • Risperidone is more effective in smaller doses
    • Typical
      • Dopamine antagonists
        • Act as antagonists in the dopamine system
        • Aim to reduce the action of dopamine
        • Strongly associated with the dopamine hypothesis
      • Synapse activity
        • Block dopamine receptors in synapses in the brain
        • Reduces the action of dopamine
        • Normalises neuro transmission in key areas of the brain
        • Reduces positive symptoms
      • Sedation
        • Chlorpromazine has an effect on histamine receptors
        • This leads to a sedation effect
        • Used to calm anxious patients when they are first admitted to hospital

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