Transcriptional Activators
- Created by: Ellie0o0o
- Created on: 28-04-15 12:36
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- Transcriptional activators
- Modular proteins
- 2 domains
- DNA-binding domain
- Zn finger
- H-T-H
- Activation domain
- May be highly acidic
- May be Glu/Pro rich
- Work independently
- Domain swap experiments
- DNA-binding domain
- Transcription factors which increase transcription
- Act cooperatively
- Enhancers
- No promoter activity
- Dramatically increase activity of other promoters
- Up/downstream
- Either orientation on the DNA
- Rely on nucleosomes to bring them close to the promoter
- Act at multiple levels
- Basal Factors
- Directly contact basal promoter
- Beneficial effects e.g. stabilise the promoter
- Activators
- Bind to DNA sequence elements
- Stimulate transcription
- Co activators
- No activation alone
- Mediate between enhancers and core promoters
- Basal Factors
- Controlled by insulators
- Also decrease heterochromatin spread
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