Transcriptional Activators

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  • Created by: Ellie0o0o
  • Created on: 28-04-15 12:36
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  • Transcriptional activators
    • Modular proteins
    • 2 domains
      • DNA-binding domain
        • Zn finger
        • H-T-H
      • Activation domain
        • May be highly acidic
        • May be Glu/Pro rich
      • Work independently
        • Domain swap experiments
    • Transcription factors which increase transcription
    • Act cooperatively
    • Enhancers
      • No promoter activity
      • Dramatically increase activity of other promoters
      • Up/downstream
      • Either orientation on the DNA
      • Rely on nucleosomes to bring them close to the promoter
      • Act at multiple levels
        • Basal Factors
          • Directly contact basal promoter
          • Beneficial effects e.g. stabilise the promoter
        • Activators
          • Bind to DNA sequence elements
          • Stimulate transcription
        • Co activators
          • No activation alone
          • Mediate between enhancers and core promoters
    • Controlled by insulators
      • Also decrease heterochromatin spread

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