three memebered ring
- Created by: S
- Created on: 26-03-17 19:33
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- Three Membered ring-kinetically favoured but thermodynamically disfavoured
- Epoxide
- Electron rich Alkene + mCPBA
- Electron poor Alkene +NaOH/H202
- Alkene + Br,H2o->HO-Br (halohydrin)
- K2O3 used to convert it into an epoxide
- Darzens Reaction ( alpha -chloro eter aldol reaction)
- Ketone/aldehyde +Me3S+I- +base
- Aziridines- similar to epoxide but less reactive to nucleophile than epoxide usully requires activation by protonation
- Alkene
- R-Br->R-N3(NaN3 SN2) thermol decomposition of azides to form nitrenes which would react to alkene to form aziridines
- Alkene
- Cyclopropane
- prepared from 4 halo bromide with NaOH
- 4 halo bromide can be synthesised via ketoester,NaOEt and epoxide then HBr and H20(-CO2)
- Alkenes and carbenes
- Carbenes
- CH2I2 + Zn ->H2C:
- Diazo compounds can undergo thermal composition to from carbenes
- Carbenes
- prepared from 4 halo bromide with NaOH
- Epoxide
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