The typical eukaryotic promoter

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  • The typical eukaryotic promoter
    • Requires: core promoter, proximal promoter element, enhancer region
    • Enhancers
      • Modular enhancers
        • position of activator binding site not important
        • Dimmer switch - different levels of activation
        • Some activity when not all activators bound
        • E.g. hunchback gene promoter - binding sites for HB and BCD interchangeable
      • Non-modular Enhancers
        • Arrangement of activator sites crucial
        • On/off switches
        • Binding of all activators necessary
        • E.g. interferon B enhancer

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