Tuberculosis (TB) - Primary Infection
- Created by: Jenny1809
- Created on: 08-06-17 11:49
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- TB - Primary Infection
- Infection by droplet inhalation (inhaled & lodges in lungs)
- Triggers immune response
- Macrophage engulfs bacteria
- Lysosome fuses with vacuole
- Bacterium broken down by lysosymes
- Granuloma with anaerobic centre forms
- Bacteria die due to oxygen starvation
- Bacteria survive, remaining latent / dormant & under control
- 'Reactivated' when immune system is weakened
- Granuloma with anaerobic centre forms
- Thick waxy cell wall protects bacteria from lysosymes
- Bacterium broken down by lysosymes
- Bacteria produce protein that inhibits fusion of lysosome & vacuole
- Bacteria proliferates creating a localised infection
- Thick waxy cell wall protects bacteria from lysosymes
- 3-8 weeks cell mediated response 'kicks in' - immune cells surround site infection
- Granuloma with anaerobic centre forms
- Bacteria die due to oxygen starvation
- Bacteria survive, remaining latent / dormant & under control
- 'Reactivated' when immune system is weakened
- Granuloma with anaerobic centre forms
- Bacteria proliferates creating a localised infection
- Lysosome fuses with vacuole
- Macrophage engulfs bacteria
- Triggers immune response
- Infection by droplet inhalation (inhaled & lodges in lungs)
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