Pharmaceutical Synthesis

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  • Pharmaceutical synthesis
    • Requires the production of a single optical isomer
    • Molecules prepared synthetically in the laboratory
      • Contain a mixture of optical isomers
    • Molecules of the same compound
      • Produces naturally by enzymes in living systems
      • Often present as one optical isomer only
    • Single optical isomer synthesis
      • More expensive (increases costs) due to the difficulty in separating the optical isomer
      • reduces possible side effects and improves pharmacological activity
    • Modern synthesis
      • uses enzymes or bacteria which promote stereoselectivity
      • using chemical chiral synthesis or chiral catalysts
      • using natural chiral molecules such as L-amno acids as sugars, as starting materials


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