Suitability of Drugs for sustained/controlled release (oral)

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  • Created by: Popstar
  • Created on: 09-04-15 18:31
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  • Suitability for oral sustained release
    • Dose
      • High potency
      • Low dose
    • Therapeutic Range
      • Large
    • Solubility/Dissolution Rate
      • Not for drug with low sol and high permeability
    • Stability in GI tract
      • Good
    • Absorption rate
      • High
    • Elimination half-life
      • Short ideally
      • too long - drug accumulation
      • too short - need large dose
    • Pre-systemic metabolism
      • not desirable

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