STAR*D Trial

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  • STAR*D Trial (Gaynes et al., 2008)
    • Method
      • Used an algorithm to guide medicine changes.
        • Initial dose of citalopram could be augmented.
        • Participants could switch to other treatments.
      • No placebo group.
    • Results
      • 33% of citalopram patients met remission.
      • 30% of drug switch patients met remission.
      • Switch to CT less rapidly effective but better tolerated.
    • Criticisms
      • Remission rate was only theoretical.
  • Remission rate was only theoretical.


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