Solid dosage form: Capsules
- Created by: Creny
- Created on: 29-03-15 20:10
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- SOLID DOSAGE FORM: CAPSULES
- Hard gelatin capsules
- cap & body
- 2 gelatin peices
- processed by collagen (hydrolysis)
- temperature sensitive
- coloured by insoluble pigments & soluble dyes
- filled with with powders
- Bloom strength
- test to measure the strength of a gel or gelatin
- 250-300 is high
- 30-100 is low
- 2 gelatin peices
- 8 capsule sizes
- higher numbers = smaller capsule
- manufacturing
- 1- conc gelatin solution prepared in hot demineralised water
- 2- pins mounted on metal bars and dipped into gelatin solution
- 3- removed with film of gelatin, rotated to ensure uniformity
- 4- passed through drying kilns, stripped off pins and cut to size
- 3- removed with film of gelatin, rotated to ensure uniformity
- 2- pins mounted on metal bars and dipped into gelatin solution
- powder filling
- bench scale
- hospitals and small industrial batches e.g. clinical trials
- industrial scale
- dependant
- uses capsule body to measure the powder
- not widely used
- uniformity depends on powder flow
- uses capsule body to measure the powder
- independent
- modern large scale industrial production
- powder hopper feeds powder into a reservoir (usually a dosator)
- dosator = tube and piston used to fill capsules
- formation of powder plug (dosage tube with spring loaded piston)
- dose determined by volume of plug in dosator
- dependant
- bench scale
- 1- conc gelatin solution prepared in hot demineralised water
- excipients
- dilutents for manageable dosing
- glidants to improve powder flow
- lubricants to reduce adhesion to metals
- drug release
- dissolution of cap shell
- gelatin caps soluble at 37oC nut virtually insoluble at 35
- dissolution of cap shell
- cap & body
- tablets are usually used where possible
- change to polymorphic form on compression
- Soft Gelatin Capsules (SEGs)
- continuous gelatin shell
- gelatin, plasticizer, water and flavors
- ads
- avoids handling and compression associated with tablets
- improved drug oral bioavaliability
- dose uniformity
- patient compliance and consumer preferance
- means of formulating liquids and low mpt drugs
- disads
- specialist equipment required
- different formulation knowledge
- increased cost
- manufacturing process
- rotary die procss
- continuous formation of a heat seal between 2 ribbons of gelatin
- rotary die procss
- continuous gelatin shell
- Hard gelatin capsules
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