Solid dosage form: Capsules

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  • Created by: Creny
  • Created on: 29-03-15 20:10
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  • SOLID DOSAGE FORM: CAPSULES
    • Hard gelatin capsules
      • cap & body
        • 2 gelatin peices
          • processed by collagen (hydrolysis)
          • temperature sensitive
          • coloured by insoluble pigments & soluble dyes
        • filled with with powders
        • Bloom strength
          • test to measure the strength of a gel or gelatin
          • 250-300 is high
          • 30-100 is low
      • 8 capsule sizes
        • higher numbers = smaller capsule
      • manufacturing
        • 1- conc gelatin solution prepared in hot demineralised water
          • 2- pins mounted on metal bars and dipped into gelatin solution
            • 3- removed with film of gelatin, rotated to ensure uniformity
              • 4- passed through drying kilns, stripped off pins and cut to size
        • powder filling
          • bench scale
            • hospitals and small industrial batches e.g. clinical trials
          • industrial scale
            • dependant
              • uses capsule body to measure the powder
                • not widely used
                • uniformity depends on powder flow
            • independent
              • modern large scale industrial production
              • powder hopper feeds powder into a reservoir (usually a dosator)
                • dosator = tube and piston used to fill capsules
              • formation of powder plug (dosage tube with spring loaded piston)
                • dose determined by volume of plug in dosator
      • excipients
        • dilutents for manageable dosing
        • glidants to improve powder flow
        • lubricants to reduce adhesion to metals
      • drug release
        • dissolution of cap shell
          • gelatin caps soluble at 37oC nut virtually insoluble at 35
    • tablets are usually used where possible
      • change to polymorphic form on compression
    • Soft Gelatin Capsules (SEGs)
      • continuous gelatin shell
        • gelatin, plasticizer, water and flavors
      • ads
        • avoids handling and compression associated with tablets
        • improved drug oral bioavaliability
        • dose uniformity
        • patient compliance and consumer preferance
        • means of formulating liquids and low mpt drugs
      • disads
        • specialist equipment required
        • different formulation knowledge
        • increased cost
      • manufacturing process
        • rotary die procss
          • continuous formation of a heat seal between 2 ribbons of gelatin

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