Solid dosage form: Tablets
- Created by: Creny
- Created on: 29-03-15 14:04
View mindmap
- Types of release
- Immediate
- Modified
- Prolonged
- maintains plasma [ ]
- slow release for drugs that cause stomach or intestinal irritation
- Local treatment for large intestinal disease
- diffusion controlled release system
- matrix system
- 1- liquid penetration of matrix and drug dissolves
- 2- [ ] gradient formed
- 3- drug diffuses pores
- factors affecting drug diffusion
- [ ] gradient
- area and distance
- diffusion coefficient of drug
- factors affecting drug diffusion
- reservoir system
- 1- liquid penetrates matrix
- 2- [ ] gradient formed
- 3- drug diffuses through membrane
- limits how much drug can get through film
- matrix system
- Dissolution controlled released system
- 1- decrease solubility of the drug by poor soluble salt form or derivative of the drug
- 2- incorporate drug into a slowly dissolving carrier
- 3- cover drug particles in slowly dissolving coating
- Drug released from a dissolution- based with different coating thickness
- Prolonged-erosion controlled release system
- rate of release controlled by erosion of the matrix
- 1- matrix material containing drug liberates from the surface
- 2- drug dissolves in intestinal fluid and absorbed
- osmosis controlled release system
- 1- osmosis transport of fluid into the release unit
- 2- dissolution of drug within unit
- 3- osmotic transport of drug through single orifice or pores
- Delayed
- Pulsatile
- Drug released from a dissolution- based with different coating thickness
- Prolonged
Comments
No comments have yet been made