Solid dosage form: Tablets

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  • Created by: Creny
  • Created on: 29-03-15 14:04
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  • Types of release
    • Immediate
    • Modified
      • Prolonged
        • maintains plasma [ ]
        • slow release for drugs that cause stomach or intestinal irritation
        • Local treatment for large intestinal disease
        • diffusion controlled release system
          • matrix system
            • 1- liquid penetration of matrix and drug dissolves
            • 2- [ ] gradient formed
            • 3- drug diffuses pores
              • factors affecting drug diffusion
                • [ ] gradient
                • area and distance
                • diffusion coefficient of drug
          • reservoir system
            • 1- liquid penetrates matrix
            • 2- [ ] gradient formed
            • 3- drug diffuses through membrane
            • limits how much drug can get through film
        • Dissolution controlled released system
          • 1- decrease solubility of the drug by poor soluble salt form or derivative of the drug
          • 2- incorporate drug into a slowly dissolving carrier
          • 3- cover drug particles in slowly dissolving coating
          • Drug released from a dissolution- based with different coating thickness
        • Prolonged-erosion controlled release system
          • rate of release controlled by erosion of the matrix
          • 1- matrix material containing drug liberates from the surface
          • 2- drug dissolves in intestinal fluid and absorbed
        • osmosis controlled release system
          • 1- osmosis transport of fluid into the release unit
          • 2- dissolution of drug within unit
          • 3- osmotic transport of drug through single orifice or pores
      • Delayed
      • Pulsatile
        • Drug released from a dissolution- based with different coating thickness

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