Sliding Filament Hypothesis
- Created by: amyxx
- Created on: 21-04-15 18:14
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- Sliding Filament Hypothesis
- Myosin - thick protein filament
- Myosin heads have binding sites for the actin molecules
- Actin - thin protein filament
- Troponin - globular protein on actin
- Tropomyosin - thread like protein that winds around the surface of actin
- Contraction - Arrival of a nerve impulse at the junction between a motor neurone and the muscle fibre
- Resting muscle fibres - thick myosin heads are prevented from attaching to the thin filaments by tropomyosin. Myofibrils have large Ca+ stores in the sarcoplasmic reticulum
- Transverse Tubules - Spaced along the sarcolemma of the muscle fibre are in-foldings spread repeatedly on the inside of the myofibril, they are near the Ca+ filled sacs
- Resting muscle fibres - thick myosin heads are prevented from attaching to the thin filaments by tropomyosin. Myofibrils have large Ca+ stores in the sarcoplasmic reticulum
- One nerve stimulation stops - the wave of electrical activity ceases; the Ca+ are pumped back to the Sarc Ret and the protein mol return to their resting shape with the tropomyosin covering the active site on the actin filament= myosin heads cannot bind
- Myosin-ATPase is no longer formed & therefore no ATP broken down - energy not released = there is not tension created in the muscle so it relaxes
- Myosin - thick protein filament
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