Sleep disorders
- Created by: ava.scott
- Created on: 06-05-15 16:31
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- Sleep disorders
- Narcolepsy
- AO1
- Hypocretin is the neurotransmitter that is thought to control wakefulness and arousal.
- Hypocretin is only produced in 10,000-20,000 cells in the hypothalamus.
- These cells can be destroyed by an immune response, causing no hypocretin to be produced.
- can also be destroyed by flu vaccination.
- This immune response occurs because of HLA complex on chormosone 6.
- People with narcolepsy therefore have vastly reduced amounts of hypocretin-producing cells.
- Research
- T E SCAMMEL
- studied a man who suffered a hypothalamic stroke, destroying hypocretin producing cells.
- he then suffered narcolepsy.
- studied a man who suffered a hypothalamic stroke, destroying hypocretin producing cells.
- NISHINO
- Found a link between low levels of hypocretin in cerebrospinal fluid and narcoleptic symptoms.
- Broughton
- Found that lifestyle changes (sleep schedules and relaxation) had a better effect on narcoleptic symptoms than drugs.
- Mignot
- Out of 16 pairs of twins, only 5 were concordant for narcolepsy.
- T E SCAMMEL
- When someone rapidly falls into a state of REM sleep.
- IDA
- reductionist
- only considers the biological mechanism behind narcolepsy, even those research shows there are environmental causes.
- prepcipating factors that causes immune response.
- makes theory less compelling as practical applications are narrower.
- reductionist
- wider evaluation
- practical applications
- hypocretin is a very large molecule and difficult to get into the brain.
- gene therapy has been considered, but is not developed.
- highly empirical research
- practical applications
- AO1
- Sleepwalking
- AO1
- Diathesis- stress model
- Diathesis refers to predisposing factors that are mainly biological.
- genetic--adenosine deanimase gene.
- linked to less release of GABA which suppresses motor activity in SWS.
- immature neural circuits means kless control over motor activity,
- this is why more children sleep walk.
- genetic--adenosine deanimase gene.
- Diathesis refers to predisposing factors that are mainly biological.
- Diathesis- stress model
- RESEARCH
- TWIN STUDIES
- BAKWIN
- 9/19 concordant in MZ.
- 1/14 were for DZ twins.
- HUBLIN
- MZ: 0.55
- DZ: 0.35
- SELF REPORTED
- 1045 MZ twins
- 1899 DZ twins
- concordance for MZ twins was 5x higher.
- BAKWIN
- Zadra
- found that after sleep deprivation, 90% of sleepwalkers sleepwalked whereas only 50% did with normal nights sleep.
- OHAYON
- 19,136 participants,
- found depressed people were 3.5x more likely to suffer sleepwalking than normal.
- Oliviero
- found that adult sleep walkers had more immature neural circuits in their brain, using MRI scans.
- TWIN STUDIES
- Research evaluation
- high population validity
- a lot of participants have been used when investigating sleep walking, so it can be generalized.
- Artifical- zadras study was in sleep lab,.
- could have provoked more or less sleep walking.
- very high control in most studies. COMPELLING EVIDENCE for sw.
- high population validity
- IDA
- Biological approach
- the theory has a biological basis as it meaures activity in SWS, and observes neural circuits.
- However, still acknowledges environmental effects, and so this diathesis-0stress model is more compelling- realistic interaction.
- Biological approach
- wider evalutation
- practical applications
- GABA pills to increase control over motor ability
- avoid alcohol to reduce SWS sleep
- criminal acts
- being able to identify the immature neural circuits or genetic test can identify 'sleep walking' as a suitable alibi.
- practical applications
- AO1
- INSOMNIA
- AO1
- Predisposing
- genetic vulnerability e.g. mutation in Cul3 neural pathway protein.
- Precipitating
- these cause insomnia to first start,
- e.g. travelling, missing a nights sleep, anxiety
- Factors which disrupt the circadian rhythm
- perpetuating
- these cause insomnia to continue
- key to chronic insomnia.
- e.g worrying about getting to sleep
- these cause insomnia to continue
- Predisposing
- RESEARCH
- Stavropoulos
- 21000 fruit flies
- those with the insomnia gene slept 1/3 of the amount of normal flies.
- Stavropoulos
- Research evaluation
- ,many people investigated--giving high genralisability for all insomniacs.
- actually still ethnocentric bias as different cultures may have different factors influencing insomnia.
- causality
- could it be that insomnia causes family/work/health problems, rather than the other way round?
- fruit fliy research is not generalizable to humans as their nature of sleep may be very different.
- ,many people investigated--giving high genralisability for all insomniacs.
- IDA
- biological approach
- but still integrated approach, making diagnosis less determinsitic
- giving more realistic approach and view of insomnia.
- but still integrated approach, making diagnosis less determinsitic
- biological approach
- wider evaluation
- practical applications
- remove perpetuating and precipitating facors.
- counselling and CBT
- remove perpetuating and precipitating facors.
- vague theory- doesn't describe the mechanism behind the gene, and how precipitating factors cause insomnia.
- practical applications
- AO1
- Narcolepsy
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