Sleep
A mindmap showing different aspects of sleep including stages, brain structures and proteins involved.
- Created by: Nathan
- Created on: 13-03-13 15:49
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- Sleep
- Brain Structures
- Reticular Activating System (RAS)
- Column of neurons in midbrain
- Active when awake, quiet when asleep
- Shows alpha waves on EEG when activated
- Locus Coeruleus
- Found in the pons
- Increases animal's sensitivity to environment
- Active when awake
- Decreased activity = onset of REM
- Raphe Nucleus
- Part of medulla & pons
- Important role in wakefulness
- Blocks activity of REM-associated neurons
- Suprachiasmatic Nuclei (SCN)
- Regulates circadian rhythms
- Input from retinal fibres
- Cholinergic Mesopontine nuclei
- Activates neurons in thalamus involved in wakefulness
- Suppresses neurons involved in sleep
- Found in midbrain
- Reticular Activating System (RAS)
- Stages of Sleep
- Stage 1
- Alpha waves
- H/R slows, muscle tension reduces
- Lasts several mins
- Stage 2
- Sleep spindles
- Theta waves
- K-complexes = sharp -'ve EEG potentials
- ~50% of sleep spent in stage 2
- Stage 3
- Delta waves
- Large amplitude, slow waves
- Sleep spindles cont.
- Stage 4
- Delta waves cont.
- Deep sleep
- Sleep walking and other anomalies occur
- REM
- Dreaming occurs
- Lots of brain activity
- Muscles paralysed
- Stage 1
- Protein-protein interactions
- Clock and Cycle proteins made by SCN cells
- Clock+Cycle= dimer
- Dimer binds to per and cry genes
- Per and Cry genes make Per and Cry proteins
- Per+Cry+Tau= complex
- Per/Cry/Tau complex binds to Per and Cry genes and silences
- Per/Cry/Tau degrades after ~20h
- Per/Cry/Tau complex binds to Per and Cry genes and silences
- Per+Cry+Tau= complex
- Per and Cry genes make Per and Cry proteins
- Dimer binds to per and cry genes
- Regulates circadian rhythms
- Clock+Cycle= dimer
- Clock and Cycle proteins made by SCN cells
- Brain Structures
- Active when awake, quiet when asleep
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