Shape and Lock and Key theory- enzymes

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  • Shape and fit
    • enzymes have a  specifically shaped active site
      • complementary to the shape of  the SUBSTRATE or molecule
        • substrates that are much smaller than the active site of an enzyme can fit
          • LOCK AND KEY THEORY
            • The substrate 'key' fits into the active site 'lock'
  • enzymes have a  specifically shaped active site
    • complementary to the shape of  the SUBSTRATE or molecule
      • substrates that are much smaller than the active site of an enzyme can fit
        • LOCK AND KEY THEORY
          • The substrate 'key' fits into the active site 'lock'
  • INDUCED FIT HYPOTHESIS
    • charges in the amino acids in the active site contribute to holding the substrate
      • substrate molecule COLLIDES with an enzyme's active site- changing the shape of the enzyme slightly
  • charges in the amino acids in the active site contribute to holding the substrate
    • substrate molecule COLLIDES with an enzyme's active site- changing the shape of the enzyme slightly

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