Schizophrenia: Genetic Factors
- Created by: Olivia
- Created on: 06-03-13 20:46
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- Schizophrenia: Genetic Factors
- Appaears to run in families
- Proportional to the amount of genes which are shared
- MZ twins: Risk = 48%
- However, vhance of developing is below 100% = other factors play a part
- DZ twins + children with one effected parent: 17%
- Grandchildren = 5%
- General population = 1%
- Twin Studies
- Asuumption = MZ twins will have a greater concordance rate
- MZ twins are genetically identical. Dz twins only share around 50% of genes
- CARDNO ET AL (2002): Used strict diagnostic criteria - showed concrodance rate of MZ twins to be 26.% and 0% for DZ
- Provides strong evidence for a genetic component
- MZ twins relatively rare in population and only 1% expected to have schz. = sample sizes small
- Twin studies dont all use same diagnostic criteria = comparisons can not always be made
- Different defintions produce different concordance rates - MCGUFFIN ET AL (1984)
- Concorndance rates can also be calculated in different ways + vary depending on method used
- Provides strong evidence for a genetic component
- Adoption studies
- Allows you to look at people with a mother with the disorder, but adoptive parents with no history of it
- KETY (1994): high rates of schiz. in individuals whose parents had the disorder, but not adoptive parents
- TIENARI (1991): Identified 155 adopted children whose biological mothers had schiz. Comapred with adopted children with no family history = 10% of group 1 developed it whereas 1% in group 2
- Strong evidence for genetic component in schiz.
- Allows you to look at people with a mother with the disorder, but adoptive parents with no history of it
- Appaears to run in families
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